Role of hepatitis B virus infection in hepatocarcinogenesis
LI Ping
WANG Maorong
Abstract：Hepatocellular carcinoma ( HCC) is one of the most common malignancy tumors in the world, which is mainly caused by Hepatitis B virus ( HBV) infection. HBV DNA integration may promote tumorigenesis via cis?activation of oncogenes or al?tered tumor suppressor activity, genomic destabilization and production of mutant HBV proteins with tumor?promoting potential. The X gene product of HBV ( HBx) has extensive trans?activating functions, which can regulate cell apoptosis, suppress cell DNA repair, in?tervene intracellular signaling pathways and change epigenetic. In this review, we summarized the research progress of prevalence and incidence of HBV related HCC, HBV DNA integration and HBx protein.
Keywords：Hepatitis B virusHepatocellular carcinomaIntegrationHepatitis B virus x protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1045-1048 )