Kinetic model for exploring dynamics of plasma EBV-DNA concentration during radiotherapy of nasopha-ryngeal carcinoma
KONG Cheng
SONG Dan
GUO Wenjie
XU Jianhua
QIAN Pudong
HE Xia
Abstract：Objective To develop a differential equation kinetic model, and explore the dynamics of plasma Epstein?Barr vi?rus(EBV)?DNA concentration for nasopharyngeal cancer(NPC) patients undergoing radiation therapy. Methods Ten NPC patients treated with intensity modulated radiotherapy from January 2013 to December 2014 were involved in this study. The content of EBV?DNA in the plasma samples were detected by using fluorescent quantitative PCR method. Results Fitting of the model to the data of plasma EBV?DNA levels allowed determination of the different parameters describing the radiosensitivity, dead?cell resolving and nec?rotic cell fraction. These parameters were correlated with patterns of the dynamics of plasma EBV?DNA level during radiotherapy, and it may be indicative of the clinical phenotype. Conclusion The model parameters may have a potential to predict biological characters of tumor, though further validation in a larger pool of samples is warranted.
Keywords：Circulating tumor DNAKineticsDifferential equationNasopharyngeal carcinomaEpstein-Barr virus-DNA( EBV-DNA)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 890-893 )