Expression and clinical significance of Snail and E-cad in metaplastic breast cancer

GAO Yue; LU Yajing; MIAO Yang; MA Changying; SUN Minghua; WU Xu; LI Dingnan; Gao Jing; ZHANG Qingyuan

Abstract：Objective To investigate the expression of Snail and E?cadherin ( E?cad) in metaplastic breast cancer ( MBC) tissues as well as their relationship with clinicopathological parameters. Methods The expression of Snail and E?cad in 58 cases of MBC were detected by immunohistochemical SP method. The corresponding clinical data were collected and then the relationship of Snail, E?cad expression and the pathological parameters of MBC were analyzed. The relationship between the Snail, E?cad expression and recurrence/metastasis were analyzed according to the follow?up data. Results In these 58 MBC patients, Snail was expressed in 45 cases ( 77?6%) and E?cad was expressed in 28 cases( 48?3%) . The expression of Snail was associated with clinical stage, lymph node metastasis and ER expression ( P<0?05) . The expression of E?cad was associated with histological grade and lymph node metasta?sis ( P<0?05) . The two proteins had no relationchip with age, tumor size, menopausal status, HER?2 expression and pathological types ( P>0?05) . The expression of Snail and E?cadherin had a negative association ( r=-0?308, P=0?019) . In MBC, both of them had relationship with local recurrence and distant metastasis ( P<0?05) . Conclusion Snail and E?cadherin may have the ability to recog?nize the tent of malignancy and invasion of MBC, which may be potential treatment target in MBC.