Hypoxia-inducible factor-1 and cancer stem cells
WANG Wenjing
MEI Mingzhu
QI Cong
Abstract：Hypoxia?inducible factor?1( HIF?1) is an oxygen?dependent transcriptional activator produced by cells and tissues under hypoxic conditions. Recent research indicates that HIF?1 is closely related with the generation and maintenance of cancer stem cells( CSCs) . Moreover, HIF?1 can regulate multiple signaling pathways related to CSCs, promote the invasion, metastasis, epithelial mesenchymal transition and angiogenesis of CSCs, enhance tumor resistance and reduce apoptosis under hypoxic conditions. Since HIF?1 is closed related with the generation and development of CSCs, the strategies targeting HIF?1 may play an important role for inhibiting and killing CSCs.
Keywords：Hypoxia-inducible factor-1Cancer stem cellsSignaling pathwaysAngiogenesisDrug-resistant
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 666-670 )