Expression of Latexin and its clinicopathological significance in esophageal squamous cell carcinoma
GU Xiaoqiang
WU Qing
Abstract：Objective To investigate the clinical significance of Latexin( LXN) in esophageal squamous cell carcinoma( ES?CC) . Methods In this study, 183 cases of ESCC tissues and para?carcinoma tissues were evaluated for LXN expression by tissue mi?croarray and immunohistochemistry. The relationship between the expression of LXN and clinical parameters( tumor size, T staging, N stagings, differentiation and TNM staging) and prognosis were analyzed. Results The positive rate of LXN expression was 48?6% in ESCC tissues, lower than 100?0% in para?carcinoma tissues. A significant correlation was observed between the expression of LXN and tumor size, T staging, N staging, tumor differentiation and TNM staging. Patients with LXN positive expression had longer overall sur?vival than those without LXN expression. Conclusion LXN was down?regulated with the development and progression of ESCC and loss of LXN expression is associated with the poor prognosis of ESCC.
Keywords：Tissue MicroarrayLatexinEsophageal squamous cell carcinoma
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 607-610 )