Clinicopathological characteristics and prognosis analysis among 1006 cases of different molecular subtypes of breast cancer in Xinjiang

QIU Xiujuan; LIU Ying; WU Erman; MENG Tao; CHENG Fang

Abstract：Objective To investigate the clinicopathological characteristics and prognosis among different molecular subtypes of breast cancer in Xinjiang. Methods Clinicopathological characteristics of 1006 cases of operable female breast cancer at Xinjiang Tumor Hospital between January 2008 and December 2010 were analyzed retrospectively. According to status of ER, PR, HER?2 and Ki?67, breast cancer patients were divided into Luminal A subtype, Luminal B subtype, HER?2 subtype and Basal?like subtype. The clinical features and prognosis among different molecular subtypes breast cancer were analyzed. Results Out of the 1006 cases, Lu?minal A subtype, Luminal B subtype, HER?2 subtype and Basal?like subtype took up 54. 8%, 18. 1%, 7. 7%, 19. 4%. Only 971 ca?ses had complete follow?up data. Local recurrence rate ( 12. 3%) and distant metastasis rate ( 27. 4%) of HER?2 subtype was significantly higher than other subtypes( P<0. 05) . The 6?year disease?free survival( DFS) rates of Luminal A subtype, Luminal B sub?type, HER?2 subtype and Basal?like subtype were 86. 8%, 75. 8%, 58. 9%, 79. 1%, and 6?year overall survival rates(OS) were 92. 1%, 83. 1%, 67. 1%, 88. 0%. Multivariate analysis revealed that lymph node status, histological grade, endocrine therapy and molecular subtypes were the independent prognostic factors of OS and DFS. Race was the independent prognostic factor of DFS ( P<0. 05) . Conclusion Luminal A is the common subtype of breast cancer in Xinjiang, and its prognosis is the best. The prognosis of HER?2 subtype breast cancer is the worst. Lymph node status, histological grade, endocrine therapy and molecular subtypes may provide important information to predict the prognosis of breast cancer. Race is the independent prognostic factor of DFS.