Research progress of the application of chimeric antigen receptor-engineered T lymphocytes for solid cancer
ZHU Tong
WANG Jiejun
ZHOU Wenli
Abstract：In recent years, the researches on chimeric antigen receptor( CAR) engineered T lymphocytes in curing cancer have made great progresses. CAR has several technical advantages, such as endowing great targeting ability to CAR?engineered T cells, breaking the state of immune tolerance and so on, which make great progress in curing Hematology. Because of existed off?target effects of solid tumor and the poor penetration of immune cells into the tumor tissue, this application is still in phase I clinical trial. This paper will make a review of the application of CAR enjineered T lymphocyte to some solid tumor experiments.
Keywords：Chimeric antigen receptor( CAR)T cellSolid tumor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 367-370 )