Application status and progression of thalidomide in treatment of solid tumors
WANG Nianfei
CHEN Zhendong
Abstract：Thalidomide originally was used for the treatment of vomiting of pregnancy, which was once forbidden in the clini?cal for teratogenic events. Basic researches have confirmed that thalidomide has the effect of anti?angiogenesis, immune adjustment and anti?inflammatory. Therefore, it is postulated that it has antitumor potential, as evident by the treatment of multiple myeloma. The treat?ment of solid tumors by thalidomide is still in the exploration stage. The existing literatures are focusing on case reports and phase Ⅰand Ⅱ clinical study with inconsistent curative effect, needing to be further confirmed by large?sample randomized controlled clinical trials. In addition, thalidomide may have a certain value to relieve the gastrointestinal reaction caused by chemotherapy and cancer ano?rexia cachexia syndrome.
Keywords：ThalidomideSolid tumorsCancer anorexia cachexia syndrome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 276-281 )