Long non-coding RNAs:A new frontier in the study of non-small cell lung cancer
ZHOU Peng
ZHANG Hanjie
LIU Xianghua
Abstract：Non?small cell lung cancer ( NSCLC) including adenocarcinoma and squamous cell carcinoma, is the predominant form of lung cancer, and accounts for the majority of cancer deaths worldwide. Despite recent advances in clinical and experimental on?cology, the prognosis of lung cancer is still unfavorable, with a 5?year overall survival rate of approximately 17%. Thus, a detailed un?derstanding of the mechanisms underlying NSCLC development and progression is essential for improving the diagnosis, prevention and treatment of this disease. Recently, accumulating evidence has shown that long non?coding RNA ( LncRNA ) may be involved in NSCLC pathogenesis, playing an important role in invasion and metastasis, proliferation, apoptosis and drug resistance of NSCLC cell. Here, we summarize the up?to?date research progress on LncRNAs in NSCLC to provide new insights into the genetic diagnosis and treatment of this deadly disease.
Keywords：Non-small cell lung cancerLong non-coding RNABiological functionMolecular mechanism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 266-270 )