TOB1 gene of antiproliferative family and cancer
HE Hongjie
YU Jingcui
Abstract：Transducer of ErbB?2?1 ( TOB1) encodes Tob1 protein which is a member of the BTG/TOB antiproliferative pro?tein family. It is involved in regulating cell cycle progression through Ras/MAPK pathway and forming complex with CCR4?Caf1 to in?hibit cell proliferation. TOB1 as a tumor suppressor gene is closely related with tumor occurrence, development and metastasis. The de?creased expression of Tob1 occurred in the majority of tumor. Its functional inactivation is associated with phosphorylation of accumula?tion and subcellular distribution, and the expression of TOB1 is associated with ionization sensitivity.
Keywords：Transducer of ErbB-2?1(TOB1)CancerGene expressionPhosphorylation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 262-265 )