The value of combined detection of serum HE4, CA153 in diagnosing breast invasive ductal carcinoma
QIN Tian
GONG Zhifeng
QIU Meiting
WU Yongxiao
Abstract：Objective To investigate the value of combined detection of serum carbohydrate antigen 153 (CA153)and human epididymis protein 4 (HE4) in diagnosing breast infiltrative ductal carcinoma. Methods In this study, 276 breast invasive ductal car?cinoma patients, 79 benign breast diseases patients and 66 healthy female volunteers were detected expressions of serum CA153 and HE4 by chemiluminescence immune analysis method and the ELISA method. The relationship between the expressions of CA153, HE4 and clinicopathological characteristics of breast infiltrative ductal carcinoma was analyzed. Results In breast invasive ductal carcinoma group, the expressions of CA153 and HE4 were (28?? 03±37?? 76)U/ L and (105?? 45±95?? 26)pmol/ L, which were significantly higher than benign disease group and the healthy control group ( P< 0?? 05). The sensitivity, accuracy, area under ROC curve( AUC) of CA153 combined with HE4 were 61?? 23%, 69?? 60% and 0?? 759, which were significantly higher than single indicator(P<0?? 05). While the statistical difference of specificity was not observed(P>0?? 05). The expressions of serum CA153 and HE4 related to whether triple?negative breast cancer, lymph node metastasis and clinical stage(P<0?? 05). Conclusion The combined detection of CA153 and HE4 can be the diagnosis index of breast infiltrative ductal carcinoma.
Keywords：Breast infiltrative ductal carcinomaCarbohydrate antigen 153Human epididymis protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 137-139 )