Expression of hedgehog signaling pathway related protein Gli1 in breast cancer and its clinical significance
FENG Fubin
ZHUANG Jing
LIU Ruijuan
WANG Congcong
TANG Shifeng
SUN Changgang
Abstract：Objective To investigate the expression of hedgehog signaling pathway related protein Gli1 in breast cancer and its clinical significance. Methods The immunohistochemical method was used to detect the expression of Gli1 in 102 cases of breast invasive ductal carcinoma and 30 cases of corresponding adjacent normal breast tissues, and then its relationship with clinicopathologi?cal features were analyzed. Results The positive expression rate of Gli1 in breast cancer tissues was 75?? 5% (77/ 102), higher than 26?? 7% (8/ 30) of paired adjacent normal tissues, with significant difference (P<0?? 05).The expression of Gli1 was related with axilla?ry lymph node metastases, estrogen receopter, but not related with age, postmenopause, tumor size, pathological stage, histological grade, progesterone receptor and human epidermal growth factor receptor 2(P>0?? 05). Conclusion Hedgehog signaling pathway relat?ed protein Gli1 is high expression in breast cancer tissues and it have some effect of negative regulation on estrogen receptor.
Keywords：Breast cancerHedgehog signaling pathwayGli1 protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 112-115 )