Association between single nucleotide polymorphisms of rs4779584, rs4444235 and the susceptibility of colo-rectal cancer in Taizhou, Jiangsu Province
LI Yingchun
LI Lijun
QIU Yun
YE Jun
SHA Min
Abstract：Objective To investigate the relationship between single nucleotide polymorphism ( SNP ) of rs4779584, rs4444235 and the susceptibility of colorectal cancer( CRC) in Taizhou area of Jiangsu province. Methods This hospital?based case?control study was conducted in 160 cases with CRC and 170 healthy controls. The association between the rs4779584, rs4444235 poly?morphism and CRC was examined by the overall odds ratio with a 95% confidence interval. Results Genotype distribution of rs4779584 C/T and rs4444235 T/C was in accordance with Hardy?Weinberg balance in both groups. Compared with the control group, the distribution of genotype and allele of two SNPs were statistically significant in disease group( P<0?05) . In rs4779584 C/T, when the CC genotype was used as the reference, the CT/TT genotypes were associated with the risk for CRC;when the CC/CT were used as the reference, the TT genotype was associated with the risk for CRC;when C allele was used as the reference, the T allele was associ?ated with the risk for CRC( P<0?05) . In rs4444235 T/C, when the TT or TT/TC were used as the reference, the CC genotype was as?sociated with the risk for CRC;when T allele was used as the reference, C allele was associated with the risk for CRC( P<0?05) . Con?clusion Carriers of TT homozygous or T allele at rs4779584 and CC homozygous or C allele at rs4444235 had increased susceptibility to development of CRC in Taizhou area of Jiangsu.
Keywords：Single nucleotide polymorphismColon cancerRectal cancerTaizhou area
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 18-22 )