Expression of FGFR1, IGF1R in resected squamous cell lung cancer and their clinical significance

ZHOU Yongfang; WANG Meng; YAN An; LI Xiaoli

Abstract：Objective To investigate the expression of fibroblast growth factor receptor 1( FGFR1) , insulin?like growth factor ( IGF1R) in resected squamous cell lung cancer tissue and their clinical significance. Methods The immunohistochemical method was applied to detect the protein expression of FGFR1, IGF1R on tissue sections from 260 squamous cell lung cancer and 40 adjacent nor?mal tissues. Then the relationship between expression of FGFR1, IGF1R and clinicopathological characteristics and prognosis. The o?verall survival( OS) was estimated using the Kaplan?Meier method. The factors affecting the prognosis of squamous cell lung cancer were analyzed by Cox multivariate survival analysis. Results The positive expression rates of FGFR1, IGF1R in squamous cell lung cancer tisssues was 32?5%(13/40)and 30?0%(12/40), higher than 32?5%(13/40)and 30?0%(12/40)of adjacent normal tissues with significant differences( P<0?05) . FGFR1 expression was related with smoking and lymph node metastasis, and the IGF1R expres?sion was only related with lymph node metastasis( P<0?05) . The median OS of patients with FGFR1 and IGF1R positive expression was 38?21, 38?48 months, lower than 42?55, 42?51 months of patients with FGFR1 and IGF1R negtive expression ( P<0?05 ) . Multivariate survival analysis showed that FGFR1, IGF1R expression and lymph node metastasis may act as independent prognostic fac?tors for squamous cell lung cancer. Conclusion Expression of FGFR1 and IGF1R may be involved in the occurrence and development of b squamous cell lung cancer.They may serve as markers for predicting the prognosis of patients with squamous cell lung cancer.