The correlation between sCTLA-4 and CD4 +CD25 +regulatory T lymphocyte and its relationship with tumor
XIE Quanqin
JIANG Jingting
WU Changping
Abstract：Regulatory T lymphocytes( Treg) play an important role in immune balance and immune regulation. Foxp3 is a symbolic molecule of regulatory T cells. Treg is considered to take part in tumor immune escape in host immune system, and is associat?ed with poor survival outcome in a variety of cancers. Cytotoxic T lymphocyte?associated antigen?4( CTLA?4) is expressed on activated T cells, and has negative control response in T cell immune response. CTLA?4 can also exist in organism circulation as a soluble form ( sCTLA?4) , and is involved in immunological homeostatic control. CTLA?4 and Treg overlap in functions, and affect the immune regu?lation process together, but the mechanism of interaction is an area for further study.
Keywords：Cytotoxic T lymphocyte-associated antigen-4( CTLA-4)Regulatory T lymphocyteTumor therapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1038-1042 )