Expressions of 14-3-3ζ and E-cadherin in stage Ⅲ lung adenocarcinoma and their clinical significance

LIU Xiaolian; XING Ying; WANG Xiaoyuan; MENG Qingwei; CAI Li

Abstract：Objective To investigate the expressions of 14?3?3ζand E?cadherin in resected stageⅢlung adenocarcinoma and their clinical significance. Methods The expressions of 14?3?3ζand E?cadherin in resected stageⅢlung adenocarcinoma tissues ob?tained from 59 patients and 43 specimens of corresponding adjacent normal alveolus tissues using immunohistochemistry,and their cor?relations with clinicopathological characteristics and prognosis of patients were analyzed. The overall survival( OS) of patients was esti?mated using the Kaplan?Meier method. The factors affecting the prognosis of stage Ⅲ lung adenocarcinoma patients were analyzed by Cox multivariate survival analysis. Results The high?level expression rate of 14?3?3ζin lung adenocarcinoma tissue was 57?63%( 34/59) , higher than 30?23( 13/43) of paired adjacent normal alveolus tissues with statistical difference( P<0?05) . The high?level expres?sion rate of E?cadherin in lung adenocarcinoma tissue was 67?79%(40/59), lower than 72?09%(31/43) of paired adjacent normal alveolus tissues without statistical difference( P>0?05) . Both of 14?3?3ζand E?cadherin expressions were correlated to differentiation( P<0?05).Positive correlation was observed between expressions of 14?3?3ζand E?cadherin (r=0?351,P=0?015).The median OS of 59 patients was 29?90 months. The median OS of patients with 14?3?3ζ and E?cadherin high?level expression both were 52?63 months, higher than 16?93 months of patients with low?level expression( P<0?05) . Multivariate survival analysis showed that 14?3?3ζwas inde?pendent prognostic indicator for resected stage Ⅲ lung adenocarcinoma patients(P<0?05). Conclusion The expressions of 14?3?3ζand E?cadherin shows a good correlation in lung adenocarcinoma tissues. Detecting the expressions of these two proteins may give a clue on prognosis in patients with stageⅢ lung adenocarcinoma.