Clinical study of paclitaxel liposome and nedaplatin combined with radiotherapy in advanced cervical canc-er

YU Jianyun; LI Linjun; CHEN Ping

Abstract：Objective To compare the effect and adverse reaction of paclitaxel liposome and nedaplatin combined with radio-therapy versus fluorouracil and nedaplatin combined with radiotherapy in advanced cervical cancer. Methods A retrospective analysis of 58 cases of advanced cervical cancer patients from May 2010 to May 2012 was made. Fifty-eight patients were divided into paclitaxel liposome and nedaplatin combined with radiotherapy group ( A group, n=30) , and the other 28 cases were treated by fluorouracil and nedaplatin combined with radiotherapy ( B group, n=28) . The radiotherapy included pelvis three-dimensional conformal radiotherapy plus brachytherapy, and the total dose of A point was 70-85Gy, while the B point was 50Gy. Chemotherapy was applied at the first day of radiotherapy. Paclitaxel liposome and nedaplatin regimen was given as follows: paclitaxel liposome 135mg/m2 iv d1 , nedaplatin 80mg/m2 iv d1 . Fluorouracil and nedaplatin regimen was applied as follows: fluorouracil 500mg/m2 iv d1-d5 , nedaplatin 80mg/m2 iv d1 . For both regimens, 21-28 days was a cycle with a total of 2 cycles. Results The treatment was completed in both groups. The ef-fective rate of A group was 76. 7% ( CR 13,PR 10,SD 6,PD 1) , and it of B group was 57. 1%( CR 9,PR 7,SD 7,PD 5) with statisti-cal difference( P<0. 05) . The 1-,2-year survival rates of A group were 100% and 92%, and the rates in B group were 88% and 75%, with statistical difference( P<0. 05) . The main adverse reactions in the two groups were myelosuppression and digestive tract reaction. The occurrence of adverse reactions in A group was lower than B group, and the difference was statistically significant (P<0. 05). Conclusion The curative effect of clinical application of paclitaxel liposome and nedaplatin combined with radiotherapy in the treat-ment of advanced cervical cancer is satisfied with tolerable adverse reactions. It is worth of clinical application.