Clinical observation of dendritic cells/cytokine-induced killer cells as maintenance therapy in patients with advanced non-small cell lung cancer
WU Biao
GUO Zengqing
WANG Lili
CHEN Shuping
YE Yunbin
HUANG Cheng
Abstract：Objective To evaluate the toxicity and efficacy of dendritic cells/cytokine-induced killer cells ( DC/CIK) as the maintenance therapy for advanced non-small cell lung cancer ( NSCLC) . Methods During January 2010 and January 2014, 120 ad-vanced NSCLC patients in stable condition were enrolled after 4-6 cycles chemotherapy containing platinum. According to the treatment, patients were assigned into control group ( n=65) and study group ( n=55) . Only the study group received DC/CIK maintenance ther-apy. Both groups were followed up and the progression free survival ( PFS) and overall survival ( OS) were compared. Moreover, the adverse reaction was recorded. Results The median PFS and OS were 5. 0 and 8. 5 months in study group and 3. 5 and 8. 0 months in control group, respectively. The median PFS was higher in study group versus control group ( P<0. 05) . No significant differences were observed on median OS between both groups. In addition, there were similar median PFS and OS between different chemotherapeutic efficacy of sub-group. The common adverse reaction included myelosuppression, fever, fatigue and joint pain. The differences of both groups were not statistically significant ( P>0. 05) . Conclusion DC/CIK as the maintenance therapy can prolong the progression of advanced NSCLC patients in stable condition with tolerable and low adverse reaction.
Keywords：Dendritic cellsCytokine-induced killer cellsMaintenance therapyNon-small cell lung cancer( NSCLC)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 917-920 )