Impact of MicroRNAs on epithelial to mesenchymal transformation and progonosis of esophageal squamous carcinoma
JIN Li
XIONG Lei
SONG Haizhu
Abstract：MicroRNAs are a kind of small non-coding RNA molecules in eukaryotes, which regulate target gene expression in the post-transcription level. MicroRNAs play a significant role in development of malignant tumors. Epithelial to mesenchymal transfor-mation occurred in cancer progression, which gets rid of the connection of the cells and acquires invasiveness and metastatic capability. This paper reviews the dysregulation of some MicroRNAs, which have diagnostic value of invasion, metastasis and prognosis of esopha-geal squamous carcinoma. Therefore, MicroRNAs will serve as new biological targets for the early diagnosis and gene therapy of esopha-geal squamous carcinoma.
Keywords：Esophageal squamous carcinomaEpithelial to mesenchymal transformationMicroRNAsPrognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 859-862 )