Expression of DMBT1 in nasopharyngeal carcinoma and its clinical significance

WANG Ruihai; CUI Dawei; SUN Guogui

Abstract：Objective To investigate the expression of deleted in malignant brain tumor 1( DMBT1) in nasopharyngeal carci-noma, and analyze its relationship with clinicopathological characteristics. Methods The DMBT1 protein expression in 69 cases of na-sopharyngeal carcinoma tissues and 36 cases of normal nasopharyngeal tissue adjacent to carcinoma were determined by immunohisto-chemistry. The relationship between DMBT1 expression and clinicopathological characteristics and prognosis were analyzed. Results The positive rate of DMBT1 protein expression in nasopharyngeal carcinoma tissues was 33?3%( 23/69 ) , significantly lower than 75?0%(27/36)in adjacent normal nasopharyngeal tissues(P<0?05). The level of DMBT1 protein expression was correlated with T stage, lymph node metastasis, clinical stage and histological grade( P<0?05) . The median overall survival time in patients with DMBT1 positive and negative expression was 60?0 months and 47?0 months respectively ( P<0?05 ) . Cox regression analysis showed that DMBT1 negative expression was an independent risk factor for prognosis of patients with nasopharyngeal carcinoma( P<0?05) . Conclu-sion DMBT1 plays an important role in the development of nasopharyngeal carcinoma, and can be used as a prognostic indicator of patients with nasopharyngeal carcinoma.