Expressions of EpCAM and Ki-67 in primary lesion and metastatic lymph nodes of triple-negative breast cancer and their clinical significance
LI Jinmei
ZHANG Jinku
ZHOU Bingjuan
CHEN Xue
MA Qiushuang
SUN Jirui
ZHANG Bingxin
Abstract：Objective To investigate the expressions of epithelial cell adhesion mole-cule( EpCAM) and Ki-67 in primary le-sion and metastatic lymph nodes of triple-negetive breast cancer( TNBC) and their clinical significance. Methods The expressions of EpCAM and Ki-67 were examined by SP immunohistochemical stain( IHC) in 81 cases of TNBC, 43 cases of metastatic lymph nodes and 20 cases of normal breast tissues. Results The overexpression rates of EpCAM and Ki-67 were 74?1% and 61?7%, respectively. Moreover, the overexpression of EpCAM and Ki-67 in TNBC was significantly higher than that in normal breast tissues( P<0?05) . The overexpression of EpCAM was correlated with differentiation grade and lymph node metastasis of TNBC( P<0?05) . On the other hand, the high expression of Ki-67 was correlated with differentiation grade, lymph node metastasis and pTNM staging of TNBC(P<0?05). The overexpression of EpCAM in metastatic lymph nodes was as high as in primary lesion of TNBC, but the high expression of Ki-67 in lymph node metastasis was higher than that in primary lesion( P<0?05) . Conclusion EpCAM and Ki-67 are expressed highly both in in primary lesion and metastatic lymph nodes of TNBC. The overexpression of EpCAM and Ki-67 can be closely related with the carci-nogenesis and progression of TNBC.
Keywords：Triple-negative breast cancer( TNBC)Epithelial cell adhesion mole-cule( EpCAM)Ki-67Immunohis-tochemical stainLymph node metastasis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 795-798 )