Correlations between dose-volume histogram parameters and radiation-induced lung injury for lung cancer patients treated with three-dimensional conformal radiotherapy and intensity-modulated radiotherapy
WANG Qiang
SHI Jian
Abstract：Objective To investigate the effect of three-dimensional conformal radiotherapy ( 3D-CRT ) and intensity-modulated radiotherapy( IMRT) on radiation-induced lung injury( RILI) and their relations with parameters of dose volume histograms ( DVH) . Methods One hundred and fifty-one cases of locally advanced lung cancer patients treated with chemoradiotherapy from sin-gle clinical center were enrolled retrospectively, including 90 cases of 3D-CRT and 61 cases of IMRT. All patients were treated with radical radiotherapy dose, 1?8-2?0Gy per fraction, 5 fracions one week, and the median prescribed dose was 60?0Gy. RILI was de-fined according to the National Cancer Institute Common Toxicity Criteria, version 3?0. The incidence of RILI in two groups was calcu-lated and its association with the parameters of DVH were analyzed. Results The incidence of RILI(≥grade 2) in 3D-CRT group was lower than that in IMRT group( 17?8% vs. 24?6%);on the contrary, the incidence of RILI(≥grade 3) in 3D-CRT group was higher than that in IMRT group(8?9% vs. 3?3%). However, there was no statistically significant difference(P>0?05). In 3D-CRT group, V20 would increase the risk of RILI( OR=3?780, P=0?030) , whereas, in IMRT group, V5 , V10 , V13 , V20 and mean lung dose would increase the risk of the RILI( OR=3?575-6?286, P=0?003-0?045) by univariate analysis. Multivariate analysis confirmed V20 was an independent risk factor. Conclusion 3D-CRT and IMRT seemed to have no significant effect on RILI(≥grade 2) , and V20 is tightly correlated with RILI.
Keywords：Three-dimensional conformal radiotherapy ( 3D-CRT )Intensity-modulated radiotherapy ( IMRT )Lung cancerRadiation-induced lung injury( RILI)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 734-738 )