Clinical research advance of TRAIL-R agonistic antibodies
ZHANG Yan
CHEN Xi
PENG Yonghai
OUYANG Xuenong
Abstract：Tumor necrosis factor-related apoptosis-inducing ligand receptor(TRAIL-R), one of important binding targets of TRAIL-mediated apoptosis, including TRAIL-R1 and TRAIL-R2( ie, death receptor 4 and death receptor 5) not only directly relates to the induction of apoptosis receptors, but also one of the most promising targets for drug design. We carried out a comprehensive review of these antibodies?preclinical and clinical studies to explore the TRAIL-mediated anti-tumor therapy and provide references for further study.
Keywords：Tumor necrosis factor-related apoptosis ligandTRAIL-R1TRAIL-R2ApoptosisAntibody
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 654-661 )