Circumventing drug resistance of tumor cells by induction of necroptosis
DENG Xiuwen
ZOU Wen
Abstract：Necroptosis is a caspase-independent, regulable programmed cell death pathway, which possesses the same mor-phological characteristics of necrosis and similar molecular biological characteristics with apoptosis. Currently, the main obstacle in chemotherapy is drug resistance of tumor cells, mainly due to multidrug resistance mediated by high expression of ATP-dependent drug transporters and the blockade of apoptosis pathway. Thus, the induction of necroptosis may act as a potentially powerful weapon to re-verse a variety of tumor resistance. This review includes three parts:necroptosis, its relation with apoptosis and autophagy, drug resist-ance mechanism of tumor cells and recent advances in the induction of necroptosis.
Keywords：NecroptosisSignal pathwayCancer drug resistanceApoptosis tolerance
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 460-464 )