Clinical observation of paclitaxel chemotherapy by low-dose dexamethasone premedication
MA Shoudong
HU Wanning
SUN Guogui
LI Haili
Abstract：Objective To observe the safety and adverse reactions of the low-dose dexamethasone premedication with paclita-xel chemotherapy, explore a new paclitaxel premedication procedure. Methods Paclitaxel(135-175mg/m2) combined with platinum drugs was used in 151 patients, 21 days was a cycle. Two kinds of the premedication procedure be used before injection of paclitaxel, one in standard premedication procedure, the other in low-dose dexamethasone premedication procedure, observe the drug safety and adverse reactions. Results Paclitaxel chemotherapy in 75 cases of low-dose dexamethasone premedication and 76 cases of standards with acute allergy rates were 8?0% and 9?2%; peripheral neuritis rate were 38?7% and 40?8%, muscle and joint pain rate were 52?0%, 53?9%. There was no statistically significant between the two groups. Conclusion There was no difference in acute allergic reaction of paclitaxel chemotherapy before the application of Low-dose dexamethasone premedication compared with standards.
Keywords：PaclitaxelPremedication procedureChemotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 443-445 )