Research advance in gamma delta T cells and its antitumor activity
SU Dan
WANG Dongliang
ZHANG Yanqiao
Abstract：Gamma delta(γδ) T cells are minor subset of T lymphocytes( 2%-5% of peripheral blood T lymphocytes) that ex-press Vγ9Vδ2 T cell receptors, mainly distributed in the mucosa-associated lymphoid tissue, are non-restricted cells of major histocom-patibility complex( MHC) , can kill various tumor cells. Many data demonstrate thatγδT cells are involved in the first line of immune defense system. In the future, adoptive γδ T cells-based cell immunotherapy will become a new strategy for cancer immunotherapy. In this review, we provide an overview of its anti-tumor mechanism and clinical application.
Keywords：Gamma delta T cellsImmunotherapyTumor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 375-378 )