Progress on correlation between Mfn2 and Ras-MAPK signal pathway in breast cancer
SHAN Xijin
ZHANG Jinghua
LI Yufeng
LIU Yan
Abstract：Mitochondrial fusion protein 2( Mfn2) is a highly conserved transmembrane GTP enzyme, which is encoded by a newly identified tumor suppressor gene Mfn2. The anti-tumor effect of Mfn2 is associated with the mitogen-activated protein kinase ( MAPK) signaling pathway. MAPK is a major downstream tributary of Ras signaling pathway, which plays an important role in the ma-lignant cells, leading to the tumor invasion and metastasis. In this review, we focus on the recent discoveries on the mechanisms in-volved in the regulation of Mfn2 and the relationship between Mfn2 and Ras-MAPK signaling pathway in breast cancer.
Keywords：Mitofusin-2(Mfn2)RasMitogen-activated protein kinase(MAPK)Signal pathwayBreast cancer
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 371-374 )