Expression of IGF-IR and SUSD3 in breast cancer and their clinical significance
YU Zhenghong
WANG Xinxing
SHI Yaqin
GU Jun
JIANG Enze
YU Bo
ZHANG Xinhua
CHEN Longbang
Abstract：Objective To investigate the expression of insulin-like growth factor-I receptor ( IGF-IR) and sushi domain-con-taining protein 3 ( SUSD3) in breast cancer tissue, and analyze their relationship with clinical parameters and the correlation between the two proteins. Methods The expression of IGF-IR and SUSD3 in 100 cases of beast cancer tissues and the corresponding adjacent normal breast tissues after surgery was detected by immunohistochemical technique MaxVisionTM , and the relationship with clinical pathological features was further analyzed. Results The positive rate of IGF-IR protein was 86.0% in breast cancer tissues, higher than 3.0% in adjacent normal breast tissues(P<0.05).The positive expression rate of SUSD3 protein was 78.0% in breast cancer tis-sues, higher than 2.0% in adjacent normal breast tissues( P<0.05) . The expression of IGF-IR and SUSD3 was related to estrogen re-ceptor and pathological types ( P<0.05) , but not with age, stage, the expression of HER-2 and Ki-67( P>0. 05) . The expression of IGF-IR and SUSD3 in breast cancer tissue was positively related ( r=0.553, P<0.01) . Conclusion The expression of IGF-IR and SUSD3 may be correlated to the occurrence and development of breast cancer. The combined detection of IGF-IR, SUSD3 and ER may play an important role in judging prognosis and guiding adjuvant therapy after surgery of breast cancer.
Keywords：Breast cancerInsulin-like growth factor-I receptor (IGF-IR)Sushi domain-containing protein 3 (SUSD3)Estrogen receptor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 303-306 )