Progression of costimulatory molecule B7-H4 in gynecological malignant tumors
HU Xiaojun
TANG Liping
DAI Weiwei
Abstract：The occurrence of tumor is not only closely related to a variety of carcinogenic factors from outside, but also keeps a close relationship with the body?s own immune response and genetic factors. B7-H4,a newly discovered immune regulatory proteins members of the family of B7, over-expresses in a number of malignant tumors. It acts as the second signal in the immune response, reg-ulates immune activity and promotes the occurrence, development and prognosis of tumors. As described below,we discussed structure, function of molecules B7-H4 and its new progression with gynecologic malignant tumors.
Keywords：B7-H4Gynecological malignant tumorImmune escapeDiagnosisImmunotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 284-286 )