Progression of interferon for biliary tract cancer
FANG Zhen
HUA Haiqing
Abstract：Interferon is a kind of cytokines with broad biological activity, it has a wide range of anti-tumor effect. Interferon family includes three types, type Ⅰ, typeⅡ and typeⅢ. Studies have shown that typeⅠ interferon especially INF-α2b which com-bined with 5-FU-based chemotherapy can play a certain role in biliary tract cancer,and INF-αcombined with HELF chemotherapy regi-men is a nice regimen for advcanced gallbladder carcinoma.In addition to better immunomodulatory effects, type Ⅱ interferon can in-hibit biliary tumor cell and promote apoptosis.When typeⅡinterferon combined with CaM-antagonist or Mifeptistone or Chinese medi-cine can be synergistic. Type Ⅲ interferons currently uses only for the treatment of viral diseases, but basic researches clearly demon-strate its anti-tumor effect, it is worth further study. This article reveiws the progression of intereron in treating biliary tract cancer.
Keywords：InterferonBiliary tract cancerCholangiocarcinomaGallbladder carcinoma
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 180-185 )