Progression of dormant cell in cancer research
YU Zhenghong
JIANG Enze
WANG Xinxing
CHEN Longbang
Abstract：Tumor dormancy is a stage of tumor development. In this stage, patients don't exhibit significant clinical symptoms. Tumor dormant cells may arise in early stage of tumor development, micrometastases period and minimal residual. The tumor dormant cells can switch between the quiescent stage and proliferative stage, which is considered the cause of tumor metastasis and recurrence. However, the mechanism of this switch is still largely unknown. The elements involved in the switch regulation include unique expres-sion patterns, immune response, and a variety of factors and signaling pathways in the microenvironment. Further study of tumor dor-mant cells may provide a therapeutic strategy for tumor metastasis and tumor recurrence, which is of great significance to clinical activi-ty and research.
Keywords：TumorDormant cellMetastasis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 172-175 )