The effect of fertility-preservation therapy for 16 cases with endometrial carcinoma
WANG Liping
QIAO Juan
LI Haiye
LUO Manling
SUN Guiqin
YIN Ailan
ZHONG Mei
Abstract：Objective To evaluate the long-term oncologic and reproductive outcomes of fertility-preservation therapy for young women with stage I endometrial carcinoma( EC) who wanted to preserve fertility. Methods The oncologic and reproductive out-comes of 16 young patients with stage I endometrial cancer treated with fertility-preservation therapy from 2005 to 2011 in Nan Fang hospital was retrospectively analyzed. The patients with positive progesterone receptor ( PR) were given megestrolacetate ( MA) orally at 160mg/day. Excluding the progress of the disease, patients with poor effect were additionally given tamoxifen( TAM) orally at 30mg/day or GnRHα. Patients with negetive PR were additionally given toremifene( TRM) at 60mg/day. Results In this research, 11 of 16 patients showed a response ( 69%) , recurrence time was 8 months ( range 5-14) . After a median follow-up time of 58 months ( range 24-108) , all patients were survival, 1 patient experienced progression of disease. Three patients succeeded in pregnancy, and 2 born babies. Conclusion Fertility-preservation therapy for young women with stage I endometrial carcinoma was safe and highly effective. However, definitive admission and close surveillance need more attention.
Keywords：Endometrial carcinomaFertility preservationProgesterone receptor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 164-167 )