Clinical value of 18 F-deoxyglucose positron emission tomography/computer tomography in diagnosis and treatment of choriocarcinoma
XIN Xiaoyan
WANG Hongbo
LAN Xiaoli
Abstract：Objective To investigate the clinical value of 18 F-deoxyglucose positron emission tomography/computer tomo-graphy ( 18 F-FDG-PET) in diagnosis and treatment of choriocarcinoma. Methods The 18 F-FDG-PET with simultaneously monitoring serum beta-human chorionic gonadotrophin (β-HCG) was carried out on 2 cases with choriocarcinoma. The increased metabolic abnor-malities in metastatic lesions of lung, liver and pelvic were observed. Results In one patient, 18 F-FDG-PET revealed the primary cho-riocarcinoma associated with pulmonary, liver and pelvis cavity metastases. The level of serumβ-HCG decreased to normal level gradu-ally and the SUVs of multiple lesions followed a normal distribution after EMA-CO chemotherapy. For another recurrence patient, serumβ-HCG increased and pathology diagnosis revealed that few viable cells existed by undergoing radical hysterectomy, but 18 F-FDG-PET detected no uptake. Conclusion 18 F-FDG-PET is useful in diagnosis and treatment of choriocarcinoma by detecting the primary and metastasis sites, and possesses higher value in assessing cytoactive. Simultaneously monitoring serum β-HCG can decrease the false positive rate and false negative rate of 18 F-FDG-PET.
Keywords：Choriocarcinoma18F-deoxyglucose positron emission tomography/computer tomography(18F-FDG-PET)Beta-human chorionic gonadotrophin(β-HCG)
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 160-163 )