Analysis of clinicopathological features and prognostic factors in cutaneous metastases of malignant tumors

ZHENG Yunyan; WU Changping; JIANG Jingting

Abstract：Objective To analyze the clinicopathological features in cutaneous metastases of malignant tumors and explore the prognostic factors. Methods The clinicopathological data, treatment and follow-up data of 48 patients with metastatic cutaneous tumors admitted by the third affiliated hospital of Soochow University from January 2006 to February 2013 were collected and retrospec-tively analyzed. The prognostic factors were analyzed by univariate analysis and Cox multivariate analysis. Results Metastatic cutane-ous tumors mainly occur in the trunk, as a single or multiple nodules and masses. The primary tumor in males mostly located in lung and colon, followed by the esophagus and stomach, and prone to metastasis to chest and abdomen. In contrast, the primary in females mostly located in breast, which were apt to metastasis to the chest. The main pathological types of metastatic cutaneous tumors were ad-enocarcinoma( 35/48) and squamous cell carcinoma( 7/48) . At end of follow-up, 20 patients died, 12 cases lost and 16 cases sur-vived. The medium survival time was 17.0 months. The prognostic factors were with or without combined therapy and other organ metas-tasis. Conclusion The prognosis in the patients with skin metastasis was poor. Other organ metastases could shorten the patients.sur-vival times. Therefore, reasonable, effective and comprehensive treatment could alleviate the symptoms, prolong the survival times and improve the quality of life.