A meta-analysis of association between COX-2 765G>C polymorphism and digestive system tumor suscepti-bility

YU Bo; GUO Zijian; ZHANG Fuzheng; DAI Guiping; LI Lihua

Abstract：Objective To evaluate the association between cyclooxygenase-2 ( COX-2) gene polymorphisms and digestive system tumor risk. Methods All studies published up to February 2013 on the association between-765G>C polymorphism of COX-2 and digestive system tumor susceptibility were identified by searching in PubMed, EMBASE and Web of Science databases. The corre-lated index was extracted for aggregate analysis in Stata/SE 12.0. Results A total of 11 083 patients and 16 856 controls from 40 pa-pers were included in the meta-analysis. Overall analysis showed that the C allele contrast model and the CG, CC/CG genotype were significantly associated with the increased digestive system tumor risk compared with the G allele contrast model and the GG genotype. Stratification analysis by ethnicity and tumor position showed that the C allele contrast model and the CG, CC/CG genotypes were sig-nificantly associated with the increased risk in Asian descendents and digestive tract tumors. No statistically significant associations were detected in Caucasian and digestive gland tumor subgroups. Stratification analysis by source of control, the C allele contrast model and the CG genotypes were significantly associated with the increased risk in the population-based ( PB) subgroup. No statistically signifi-cant associations were detected in hospital-based ( HB) subgroup. Conclusion The COX-2-765G>C polymorphism is significantly as-sociated with digestive system tumor susceptibility, especially among Asian populations.