Clinical efficacy of adaptive radiotherapy with helical tomotherapy in the treatment of lung cancer
GUO Yihang
WANG Lipeng
LI Weiyuan
ZHANG Manyu
FENG Qing
ZHAO Jiaming
Abstract：Objective To investigate the clinical efficacy of adaptive radiotherapy with helical tomotherapy(TOMO)in the treatment of lung cancer.Methods Sixty patients with lung cancer who underwent radiotherapy between September 2020 and December 2023 were selected.They were divided into the control group(n=30)and the observation group(n=30)according to different radiotherapy methods.Thirty patients who underwent conventional non-adaptive radiotherapy with linear accelerator were included in the control group,and thirty patients who underwent adaptive radiotherapy with TOMO were included in the observation group.The short-term efficacy and the incidence of radiotherapy-related adverse reactions were compared between the two groups.K-M survival curve was drawn to analyze progression-free survival(PFS)and overall survival(OS)of the two groups.Univariate Cox regression analysis and multivariate analysis were used to identify factors affecting the survival of patients undergoing radiotherapy for lung cancer.Results The objective response rate and disease control rate of the observation group[83.33%(25/30)and 96.67%(29/30)]were higher than those of the control group[56.67%(17/30)and 73.33%(22/30)](P<0.05),while the total incidence of radiotherapy-related adverse reactions in the observation group[10.00%(3/30)]was lower than that in the control group[43.33%(13/30)](P<0.05).K-M survival curve showed that cumulative PFS and cumulative OS of the observation group(39.70% and 45.40%)were higher than those of the control group(16.20% and 21.70%)(P<0.05).Univariate and multivariate Cox regression analyses showed that TNM staging and radiotherapy method were factors affecting PFS and OS of patients undergoing radiotherapy for lung cancer(P<0.05).Conclusion Applying adaptive radiotherapy with TOMO to treat lung cancer can significantly improve short-term efficacy,reduce adverse reactions and enhance prognosis.However,TNM staging and radiotherapy method are factors affecting PFS and OS,which deserves close attention in clinical practice.
Keywords：lung cancerhelical tomotherapyadaptive radiotherapyradiotherapy-related adverse reactionsprognosisinfluencing factorsTNM stagingradiotherapy method
Publication Date：2026-03-28
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：6( 26-30,36 )