Observation on the clinical effect on Anshen Dingzhi formula in the treatment of insomnia with heart-spleen deficiency syndrome

XU Jing; ZUO Qiulin; LIANG Jun

doi:10.3969/j.issn.1002-3429.2026.04.015

Abstract：Objective To investigate the effect of Anshen Dingzhi formula on insomnia with heart-spleen deficiency syndrome.Methods From January 2020 to January 2023,86 insomnia patients with heart-spleen deficiency syndrome were selected.According to the random number table method,they were divided into the observation group and the control group,with 43 patients in each group.Both groups were given basic treatment for insomnia.The control group was treated with Estazolam tablets,and the observation group was treated with traditional Chinese medicine(TCM)Anshen Dingzhi formula.Both groups were treated for 4 weeks.The TCM syndrome score,Pittsburgh Sleep quality Index(PSQI)score,sleep dysfunction rating scale(SDRS)score,serum levels of 5-hydroxytryptamine(5-HT),γ-aminobutyric acid(GABA),norepinephrine(NE)and total effective rate were compared between the two groups before and after treatment.Results Compared with those before treatment,the TCM syndrome scores after treatment were decreased in the two groups,which were lower in the observation group than in the control group(P＜0.05).After treatment,the PSQI scores and SDRS scores of the two groups were lower than those before treatment,and lower in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,the levels of serum 5-HT and GABA in the two groups were higher than those before treatment,while the level of NE was lower than that before treatment(P＜0.05).After treatment,the serum levels of 5-HT and GABA in the observation group were higher than those in the control group,while the NE level was lower than that in the control group(P＜0.01).The total effective rate of the observation group[97.67％(42/43)]was higher than that of the control group[74.42％(32/43)](P＜0.01).The total incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion Anshen Dingzhi formula can reduce TCM syndrome scores,improve sleep quality,alleviate sleep disorders,and have a significant effect on treating insomnia with heart-spleen deficiency syndrome.Its mechanism may be related to regulating the levels of 5-HT,GABA,and NE.