Observation on the effects of Shugan Tiaoshen acupuncture combined with auricular point therapy in PCID patients with spleen deficiency and liver depression syndrome
GUO Xiaomin
LI Yuchao
Abstract：Objective To investigate the effects of Shugan Tiaoshen acupuncture combined with auricular point therapy on depression severity and serum levels of interleukin-1 β(IL-1β),C reactive protein(CRP)and interleukin-6(IL-6)in patients with post-cerebral infarction depression(PCID)and spleen deficiency and liver depression syndrome.Methods In total,103 patients with PCID admitted between March 2022 and March 2024 were selected and divided into the control group(n=52)and the observation group(n=51)according to random number table method.The control group was given auricular point therapy combined with sham acupuncture,while observation group was supplemented with Shugan Tiaoshen acupuncture.The clinical therapeutic effect in the two groups was observed.The depression severity[Hamilton depression scale-17(HAMD-17)],cognitive function[mini-mental state examination(MMSE)],nerve function[national institutes of health stroke scale(NIHSS)],levels of serum inflammatory factors(CRP,IL-1β,IL-6)and brain-related biomarkers[brain-derived neurotrophic factor(BDNF),glial fibrillary acidic protein(GFAP),S100B protein],and the safety were compared between the two groups before and after treatment.Results The total response rate of observation group was higher than that of control group[90.20％(46/51)vs.71.15％(37/52),P＜0.05].After treatment,scores of HAMD-17 and NIHSS were decreased in both groups,which were lower in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,MMSE score and BDNF level were increased in both groups,which were higher in the observation group than in the control group(P＜0.05,P＜0.01).After treatment,levels of CRP,IL-1β,IL-6,GFAP and S100B were decreased in both groups,which were lower in the observation group than in the control group(P＜0.05,P＜0.01).There was no significant difference in total incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion Shugan Tiaoshen acupuncture combined with auricular point therapy can effectively improve depressive symptoms and nerve function in patients with PCID and spleen deficiency and liver depression syndrome,regulate levels of serum inflammatory factors and brain-related biomarkers,with good safety.
Keywords：post-cerebral infarction depressionShugan Tiaoshen acupunctureauricular point therapydepressive symptomcognitive functioninterleukin-1βbrain-derived neurotrophic factor
Publication Date：2026-02-28
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：6( 83-88 )