Clinical application and effect of traditional Chinese medicine fumigation and washing and high-intensity focused ultrasound in the treatment of vulvar leukoplakia with damp-heat downward infusion syndrome
JI Lingxiao
ZHANG Junjie
LI Jialin
YE Ronglei
WANG Xiaoyu
Abstract：Objective To investigate the clinical efficacy of traditional Chinese medicine(TCM)fumigation and washing and high-intensity focused ultrasound in the treatment of vulvar leukoplakia with damp-heat downward infusion syndrome.Methods From December 2021 to December 2022,the clinical data of patients with vulvar leukoplakia with damp-heat downward infusion syndrome were retrospectively analyzed.According to the treatment method,the patients were divided into ultrasound treatment group(n=97)and combination treatment group(n=103).The ultrasound treatment group was treated with high-intensity focused ultrasound,and the combination treatment group was treated with high-intensity focused ultrasound combined with TCM.The clinical effects and adverse reactions of the two groups were compared.The improvement of skin symptoms(vulvar pruritus,vulvar depigmentation,vaginal pain),inflammatory factor levels[hypersensitive C reactive protein,interleukin-6,procalcitonin]and quality of life[dermatology life quality index]were compared before treatment and at 1 month after treatment,and the recurrence after treatment in the two groups was recorded.Results The total effective rate in combination treatment group was higher than that in ultrasound treatment group(P＜0.05).During treatment,there were no significant differences in the total incidence rates of adverse reactions between the two groups(P＞0.05).At 1 month after treatment,the skin symptom improvement score,inflammatory factor levels and DLQI score in both groups were significantly declined compared with those before treatment,which were lower in combination treatment group than in ultrasound treatment group(P＜0.05,P＜0.01).At 6 months,1 year and 2 years after treatment,the recurrence rate was lower in combination treatment group than in ultrasound treatment group(P＜0.05,P＜0.01).Conclusion TCM fumigation and washing combined with high-intensity focused ultrasound has significant efficacy in the treatment of vulvar leukoplakia with damp-heat downward infusion syndrome,and it can effectively relieve the clinical symptoms and skin symptoms of patients,reduce the levels of inflammatory factors and enhance the quality of life of patients,with good safety.
Keywords：vulvar leukoplakiadamp-heat downward infusion syndrometraditional Chinese medicine fumigation and washinghigh-intensity focused ultrasoundhigh-sensitivity C reactive proteininterleukin-6dermatology life quality index
Publication Date：2026-02-28
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：6( 78-82,88 )