Analysis of pathological misdiagnosis of borderline clear cell tumor of the ovary
ZHANG Sen
CHEN Lijie
HAN Jiangxue
WENG Haiyan
Abstract：Objective To explore the clinical and pathological characteristics,causes of misdiagnosis,and preventive measures of ovarian borderline clear cell tumor(CCBOT),and to improve the level of clinical diagnosis and treatment.Methods A retrospective analysis was conducted on the clinical and pathological data of one patient with CCBOT who was admitted in June 2022,and relevant literature was reviewed.Results In this study,a middle-aged female patient visited the hospital due to a pelvic mass detected during physical examination.The ultrasound examination revealed a cystic-solid lesion in the left ovary,and during the operation,a right ovarian cystic-solid mass was also identified;therefore,a laparoscopic bilateral salpingo-oophorectomy(BSO)was performed.The pathological examination of intraoperative frozen section suggested a sex cord-stromal tumor.Postoperative pathological and immunohistochemical examinations confirmed the diagnosis of CCBOT(right adnexa),with focal carcinomatous transformation,associated with endometriosis in the adjacent ovarian tissue.The pathological misdiagnosis lasted one week.Based on the pathological examination results,the patient was readmitted for a second operation for additional treatment(laparoscopic total hysterectomy+greater omentum resection+bilateral pelvic lymph node dissection).The postoperative pathological examination confirmed that the greater omentum and pelvic lymph nodes did not show tumor involvement.The patient recovered well after the operation,and the condition was stable.Follow-up for 34 months showed no tumor recurrence or metastasis.Conclusion CCBOT is a rare borderline tumor that originates in the ovary.Its morphology is prone to confusion with various ovarian tumors,making clinical diagnosis quite challenging.Enhancing awareness of clinical assessment,optimizing pathological diagnostic procedures,and strengthening multidisciplinary collaboration can reduce clinical misdiagnosis.However,a definitive diagnosis still requires combined pathological and immunohistochemical examinations.
Keywords：ovaryborderline clear cell tumormisdiagnosissex cord-stromal tumorclear cell carcinomaadenomyosisimmunohistochemistrydifferential diagnosis
Publication Date：2026-02-13
Online Publishing Date：2026-03-05(First online date of this platform, not the publication date of the document)
Pages：6( 20-25 )