Association of TCBI with urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus and their clinical significance
DING Yi
SHANG Dongsheng
DENG Xia
WANG Linxian
BU Hanli
ZHUANG Qin
Abstract：Objective To investigate the association of triglycerides(TG)-total cholesterol-(TC)-body weight(BW)index(TCBI)with urinary albumin/creatinine ratio(UACR)in type 2 diabetes mellitus(T2DM)patients.Methods A total of 600 patients with T2DM who were treated between January 2018 and November 2023 were enrolled in this study.Clinical data and several parameters,such as TC,TG,TC,and UACR,were collected.According to calculated TCBI values,patients were divided into low TCBI(L-TCBI)group(n=200),medium TCBI(M-TCBI)group(n=200)and high TCBI(H-TCBI)group(n=201).According to UACR,patients were divided into normal albuminuria group(n=314),microalbuminuria group(n=232)and macroalbuminuria group(n=54).Pearson correlation analysis was applied to examine the correlation between TCBI and clinical characteristics in patients with T2DM.Multivariate logistic regression analysis was used to identify risk factors for albuminuria in T2DM patients and to evaluate the predictive value of TCBI for the risk of albuminuria onset.Results The logarithmically transformed UACR(lgUACR)was higher in the H-TCBI group than in the L-TCBI and M-TCBI groups,and higher in the M-TCBI group than in the L-TCBI group(P＜0.05).The TCBI level in the macroalbuminuria group was higher than that in both the normal albuminuria and microalbuminuria groups,and higher in the microalbuminuria group than in the normal albuminuria group(P＜0.05).TCBI showed negative correlations with age(r=-0.14,P＜0.01),disease duration(r=-0.11,P＜0.01),and high-density lipoprotein cholesterol(r=-0.12,P＜0.01),while it showed positive correlations with lgUACR(r=0.27,P＜0.01),body mass index(r=0.30,P＜0.01),glycated hemoglobin(r=0.12,P＜0.01),fasting blood glucose(r=0.19,P＜0.01),low-density lipoprotein cholesterol(r=0.23,P＜0.01),blood urea(r=0.09,P＜0.01),blood uric acid(r=0.25,P＜0.01),and the logarithmically transformed insulin resistance index(r=0.14,P＜0.01).Multivariate logistic regression analysis indicated that TCBI was an independent risk factor for albuminuria(P＜0.01).The area under the receiver operating characteristic curve of TCBI in predicting albuminuria was 0.715,with a sensitivity of 63.6％and a specificity of 71.0％.Conclusion In T2DM patients,increased TCBI is related to elevated UACR,increasing the risk of albuminuria and having certain predictive value for albuminuria.
Keywords：type 2 diabetes mellitusalbuminuriatriglyceridestotal cholesterolbody weightnutritional indexurinary albumin/creatinine ratiodiabetic nephropathy
Publication Date：2026-01-28
Online Publishing Date：2026-02-05(First online date of this platform, not the publication date of the document)
Pages：8( 41-48 )