Application value of Prourokinase combined with Nicorandil during emergency PCI for elderly patients with acute STEMI
WANG Yuxin
CUI Xiaolin
JIN Zi
Abstract：Objective To investigate the application value of Prourokinase combined with Nicorandil in emergency percutaneous coronary intervention(PCI)for elderly patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 126 elderly patients with acute STEMI who underwent emergency PCI from December 2020 to December 2023 were selected as the research subjects for retrospective analysis.The patients were divided into two groups based on whether Prourokinase treatment was performed during PCI.The control group was treated with Nicorandil(n=82),and the research group was supplemented with Prourokinase on this basis(n=44).The myocardial injury markers[creatine kinase(CK),cardiac troponin I(cTnI),myocardial creatine kinase isoenzyme(CK-MB)],cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular end-systolic volume index(LVESVI),left ventricular end-diastolic volume index(LVEDVI)],and no-reflow/slow blood flow,as well as incidence of major adverse cardiovascular events(MACE)and adverse reactions were compared between the two groups.Results The incidence of no-reflow/slow blood flow during PCI in the research group was 18.19％(8/44),which was lower than that[35.36％(29/82)]in the control group(P＜0.05).At 1 week after the operation,the levels of CK,cTnI,CK-MB,LVESVI and LVEDVI in both groups decreased compared with those before the operation,which were lower in the research group than in the control group(P＜0.05).At 1 week after the operation,the LVEF levels in both groups increased compared with those before the operation,and the levels in the research group were higher than those in the control group(P＜0.05).Within 6 months after the operation,there was no significant difference in the incidence of MACE between the two groups(P＞0.05),No significant difference in the incidence of adverse reactions between the two groups from the initiation of medication to 7 d after surgery(P＞0.05).Conclusion Prourokinase combined with Nicorandil can effectively prevent the phenomenon of no-reflow/slow blood flow in elderly patients with acute STEMI during emergency PCI,effectively improve myocardial perfusion,enhance cardiac function,and has high safety.
Keywords：acute ST-segment elevation myocardial infarctionProurokinasepercutaneous coronary interventionno-reflowslow blood flowmyocardial injurymajor adverse cardiovascular events
Publication Date：2026-01-13
Online Publishing Date：2026-01-23(First online date of this platform, not the publication date of the document)
Pages：6( 24-29 )