Clinical efficacy comparison between wound-care liquid dressing and silver ion dressing in the treatment of diabetic foot ulcers
WANG Gang
JIANG Yibiao
LIU Zhenbin
LI Menghu
WANG Bowen
LEI Zhangcheng
LU Dongya
WANG Yucheng
Abstract：Objective To evaluate the clinical efficacy and safety of wound-care liquid dressing in the treatment of diabetic foot ulcers(DFU).Methods Fifty patients with Wagner Grade Ⅱ-Ⅲ DFU admitted between October 2024 and May 2025 were assigned to the observation group(n=26)and the control group(n=24)using a random number table method.The observation group received wound-care liquid dressing(main components:chitosan and sodium carboxymethylcellulose),while the control group received silver ion dressing.The two groups were compared in terms of reduction rate of ulcer area,growth rate of granulation tissue,decrease rate of inflammatory markers[white blood cell count(WBC),neutrophil count(NEUT),C reactive protein(CRP),erythrocyte sedimentation rate(ESR),procalcitonin(PCT)],wound exudate score,changes in bacterial load,and incidence of adverse reactions.Results The ulcer area reduction rate,granulation tissue growth rate,and the proportion of patients with no wound exudation in the observation group were significantly higher or larger than those in the control group at all time points after treatment(P＜0.01).The bacterial quantification in the observation group was lower than that in the control group at 7 and 14 d after treatment,and the decrease in bacterial load was greater in the observation group than in the control group(P＜0.01).The reduction rates of WBC,NEUT,CRP,ESR,and PCT in the observation group were significantly higher than those in the control group(P＜0.01).The incidence of adverse reactions was not statistically significant between the two groups[0(0/26)vs.8.3％(2/24)](P＞0.05).Conclusion Through the synergistic action of their main components,chitosan and sodium carboxymethylcellulose,wound-care liquid dressing can significantly promote the healing of DFU wounds,effectively control infection and inflammatory responses,and demonstrate good safety.
Keywords：diabetic foot ulcerswound-care liquid dressingchitosancarboxymethylcelluloseexudatebacterial quantificationerythrocyte sedimentation rate
Publication Date：2025-12-28
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：6( 76-81 )