Effects of hyperbaric oxygen therapy at different frequencies combined with rTMS on cerebral hemodynamic parameters and cognitive function in patients with cerebral infarction
XU Da
ZHENG Xiaobin
HAN Yuhui
LI Qingjin
Abstract：Objective To investigate the effects of different frequencies of hyperbaric oxygen combined with repetitive transcranial magnetic stimulation(rTMS)on cerebral hemodynamic parameters and cognitive function in patients with cerebral infarction.Methods A total of 100 patients with cerebral infarction who were treated from October 2022 to October 2024 were selected and divided into the control group(n=34),the low-frequency group(n=33),and the high-frequency group(n=33)according to random number table method.The control group received rTMS therapy five times a week for four consecutive weeks.The low-frequency and high frequency groups received additional hyperbaric oxygen therapy on the basis of the control group.The low-and high-frequency groups underwent hyperbaric oxygen therapy three and five times a week respectively for four consecutive weeks.The clinical efficacy of the three groups was evaluated,and changes in cerebral hemodynamic parameters[mean velocity(MV),resistance index(RI),and pulsatility index(PI)],neurological function[modified Rankin Scale(mRS)],language function[Aphasia Battery of Chinese(ABC)],and cognitive function[Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),and Neurobehavioral Cognitive Status Examination(NCSE)]before and after treatment were compared.Additionally,the incidence of adverse reactions was statistically analyzed.Results After treatment,the total effective rates in the low-frequency and high-frequency groups[87.88％(29/33)and 93.94％(31/33),respectively]were significantly higher than that in the control group[70.59％(24/34)],which were significantly higher in the high-frequency group than in the low-frequency group(P＜0.05).The MV levels in the low-frequency and high-frequency groups were significantly higher than those in the control group,which were significantly higher in the high-frequency group than in the low-frequency group(P＜0.05).The RI levels,PI levels,and mRS scores in the low-frequency and high-frequency groups were significantly lower than those in the control group,which were significantly lower in the high-frequency group than in the low-frequency group(P＜0.05).The ABC,MMSE,MoCA and NCSE scale scores in the low-frequency and high-frequency groups were significantly higher than those in the control group,which were significantly higher in the high-frequency group than in the low-frequency group(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion Hyperbaric oxygen therapy combined with rTMS can safely and effectively improve cerebral blood perfusion,cognitive function,and neurological function in patients with cerebral infarction,and the high-frequency hyperbaric oxygen and rTMS regimen demonstrates superior clinical efficacy.
Keywords：cerebral infarctionhyperbaric oxygenrepetitive transcranial magnetic stimulationmean velocityresistance indexpulsatility indexmodified Rankin ScaleMini-Mental State Examination
Publication Date：2025-12-28
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：7( 26-31,40 )