Influencing factors of immediate breast reconstruction after breast cancer surgery and establishment and verification of early warning model
LIU Xiaojun
ZHANG Yang
HAO Peipei
YANG Hongying
Abstract：Objective To investigate the influencing factors of the effect of immediate breast reconstruction after breast cancer surgery and to construct an early warning model.Methods A total of 685 patients who underwent immediate breast reconstruction after breast cancer surgery from January 2015 to May 2023 were selected.According to the effect of immediate breast reconstruction after surgery,they were divided into excellent effect group and poor effect group.Univariate and multivariate logistic regression analyses were used to analyze the influencing factors of poor immediate breast reconstruction after breast cancer surgery.Based on the results of multivariate logistic regression analysis,a nomogram model of poor immediate breast reconstruction after breast cancer surgery was constructed and verified.Results The poor rate of immediate breast reconstruction after breast cancer surgery was 12.12%(83/685).Factors such as body mass index(BMI),administration of chemotherapy,presence of comorbid hypertension,presence of comorbid diabetes,the type of breast reconstruction material,presence of the nipple-areola complex(NAC)preservation,and presence of the thorax type and symmetry analysis before surgery were influencing factors for poor outcomes in immediate breast reconstruction after breast cancer surgery(P<0.05).The area under the receiver operating characteristic(ROC)curve(AUC)of the nomogram prediction model for poor immediate breast reconstruction after breast cancer surgery was 0.826(95%CI:0.778,0.874).The prediction probability of the model was basically consistent with the actual observation results,and it had a high clinical positive net benefit in the range of 0.18-0.79 threshold probability.Conclusion The influencing factors of poor immediate breast reconstruction after breast cancer surgery are BMI,type of breast reconstruction material,and presence of NAC preservation.The constructed nomogram prediction model predicts poor postoperative efficacy,calibration,and good clinical efficacy.It can be used to guide the evaluation and decision-making of poor immediate breast reconstruction after breast cancer surgery.
Keywords：breast cancerbreast reconstructioninfluencing factorsbody mass indextype of breast reconstruction materialpreservation of the nipple areola complexearly warning model
Publication Date：2025-11-13
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：7( 37-43 )