Comparison of the benefits of prone position ventilation combined with different glucocorticoid applications in patients with severe pneumonia
MI Danli
LIU Ying
ZOU Keyuan
LI Junmei
Abstract：Objective To compare and analyze the clinical effect of prone position ventilation(PPV)combined with Dexamethasone or Methylprednisolone in the treatment of severe pneumonia.Methods A total of 61 patients with severe pneumonia who were treated with PPV from January to November 2023 were selected,including 31 patients treated with Dexamethasone(Dexamethasone group)and 30 patients treated with Methylprednisolone(Methylprednisolone group).The clinical efficacy,recovery process and adverse reactions were compared between the two groups.Blood gas analysis,inflammatory indexes and immune function[regulatory T lymphocyte(Treg),helper T lymphocyte 17(Th17),CD4+/CD8+,CD3+]were statistically compared between the two groups before and after treatment.Results There was no significant difference in efficacy distribution,recovery process and weaning failure rate between Dexamethasone group and Methylprednisolone group(P>0.05).After treatment,the levels of blood lactic acid,partial pressure of carbon dioxide in arterial blood,Th17,serum tumor necrosis factor-α,high mobility group protein B-1,C-reactive protein and interleukin-6 in the two groups were lower than those before treatment,while partial pressure of oxygen in arterial blood,oxygenation index and Treg were higher than those before treatment(P<0.05).However,there was no significant difference in the above indexes between the two groups after treatment(P>0.05).After treatment,CD4+/CD8+and CD3+in the Dexamethasone group were lower than those before treatment,and lower than those in the Methylprednisolone group(P<0.05).The incidence of nausea and vomiting in the Dexamethasone group was 19.35%(6/31),which was higher than that in the Methylprednisolone group 0(P<0.05).Conclusion The clinical effect of PPV combined with Dexamethasone or Methylprednisolone in the treatment of severe pneumonia is similar,which can improve the blood gas analysis index and inhibit the inflammatory response.However,Dexamethasone can cause immune function damage,while Methylprednisolone has fewer effects and higher safety.
Keywords：severe pneumoniaprone position ventilationDexamethasoneMethylprednisoloneinflammatory responseimmune functioncurative effect
Publication Date：2025-10-13
Online Publishing Date：2025-10-21(First online date of this platform, not the publication date of the document)
Pages：6( 83-88 )