Study on the pathogenesis of idiopathic pulmonary fibrosis
WANG Jia
ZHI Zheng
WANG Jiepeng
XI Zihuan
YAN Yanan
Abstract：Idiopathic pulmonary fibrosis(IPF)is a chronic,progressive and irreversible lung disease with an increasing prevalence worldwide.It cannot be cured by existing drugs and lung transplantation is limited.The pathogenesis of IPF initiates with epithelial injury and abnormal repair,and fibroblast activation and proliferation,extracellular matrix remodeling imbalance,immune inflammatory response,genetic factors,oxidative stress and endoplasmic reticulum stress,vascular abnormalities and epigenetic regulation abnormalities are all involved.Numerous signaling pathways such as TGF-β/Smads and Wnt/β-catenin intertact with each other to promote fibrosis.According to the theory of traditional Chinese medicine,IPF is mostly classified into the categories of"lung atrophy"and"lung obstruction",and the disease is located in the lung,spleen and kidney.The disease nature is characterized by deficiency in the root and excess in the branch.Deficiency,phlegm,blood stasis,and toxin run through the entire course of the disease,and there is an inherent connection with the pathological mechanisms of modern medicine.This article aims to provide a theoretical basis for understanding the pathogenesis of IPF and exploring effective treatment strategies.
Keywords：idiopathic pulmonary fibrosispathogenesissignaling pathwaysTCM etiology and pathogenesisreview
Publication Date：2025-09-13
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：6( 105-110 )