Impact of hyperbaric oxygen-assisted therapy on the levels of serum inflammatory factors and ox-LDL in wake-up stroke patients without receiving intravenous thrombolytic therapy
LI Ran
ZHANG Yun
YUE Binghong
ZHI Yongyi
ZHAI Xiaoyuan
LIU Xingliang
Abstract：Objective To explore the impact of hyperbaric oxygen-assisted therapy(HBOT)on the levels of serum inflammatory factors and oxidized low-density lipoprotein(ox-LDL)in patients with wake-up stroke(WUS)who did not receive intravenous thrombolytic therapy.Methods A total of 94 patients with WUS admitted from November 2022 to December 2023 were selected and divided into the observation group and the control group,with 47 patient in each group,using a random number table.The observation group was treated with conventional drugs combined with HBOT,while the control group was treated with conventional drugs.Both groups were treated for one month.The levels of serum inflammatory factors[high-sensitivity C reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and ox-LDL before and after treatment were compared between the two groups.The changes in the scores of the National Institutes of health stroke scale(NIHSS)and the Modified rankin scale(mRS)at 7,14,and 30 d after the onset of the disease,and the safety of treatment were evaluated.Results After treatment,the levels of serum hs-CRP,IL-6,TNF-α and ox-LDL in both groups decreased,which were lower in the observation group than in the control group(P<0.05,P<0.01).The NIHSS and mRS scores of both groups at 7,14 and 30 d after treatment were significantly lower than those before treatment(P<0.05).At 14 and 30 d aftertreatment,the NIHSS and mRS scores of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion HBOT adjuvant therapy can reduce the levels of serum inflammatory factors and ox-LDL in WUS patients who have not received intravenous thrombolytic therapy,improve the degree of neurological deficits and prognosis,and has good safety.
Keywords：hyperbaric oxygenwake-up strokeintravenous thrombolysishigh-sensitivity C reactive proteininterleukin-6tumor necrosis factor-αoxidized low-density lipoprotein
Publication Date：2025-09-13
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：5( 65-69 )