Efficacy of Jian'er Qiangshen Electuary Combined with Montelukast Sodium in Children Having Bronchial Asthma in the Chronic Persistent Phase with Lung-spleen Qi Deficiency and Phlegm-turbidity Syndrome and Its Impact on Intestinal Flora

LI Yanlin; MIAO Chunjie; XI Lihui

doi:10.3969/j.issn.1002-3429.2025.15.019

Abstract：Objective To explore the efficacy of Jian'er Qiangshen electuary combined with Montelukast Sodium on the lung-spleen qi deficiency and phlegm-turbidity syndrome in children with bronchial asthma in the chronic persistent phase and its impact on intestinal flora.Methods A retrospective selection was made of 150 children with bronchial asthma in the chronic persistent phase suffering from lung-spleen qi deficiency and phlegm-turbidity syndrome who visited the hospital from June 2022 to September 2024.They were divided into the Montelutast Sodium Chewable tablet group(Group A),the Jianer Qiangshen electuary group(Group B),and the combined medication group(Group C)by the random number table method,with 50 patients in each group.The scores of the Childhood Asthma Control Test Questionnaire(C-ACT),pulmonary function indicators[peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC],and the levels of serum inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),eosinophils(EOS)],immunoglobulin(IgA,IgG,IgE)levels,as well as intestinal flora conditions and the occurrence of adverse reactions,were compared among the three groups before and after treatment.Results After treatment,the C-ACT scores of all three groups increased compared with those before treatment,and the C-ACT score of group C was higher than that of groups A and B(P<0.05).After treatment,PEF,FEV1,FVC,and FEV1/FVC in all three groups increased compared with those before treatment,and each index in group C was higher than that in groups A and B(P<0.05).After treatment,the levels of hs-CRP,TNF-α and EOS in all three groups were lower than those before treatment,and the levels in group C were lower than those in groups A and B(P<0.05).After treatment,the levels of IgA and IgG in the three groups increased compared with those before treatment,the level of IgE decreased compared with that before treatment,and the levels in group C were superior to those in group A(P<0.05).After treatment,the colony counts of Lactobacillus and Clostridium butyricum in the three groups increased compared with those before treatment,while the colony count of Escherichia coli decreased compared with that before treatment;the colony count in group C was superior to that in groups A and B(P<0.05).No obvious adverse reactions occurred in the three groups of children with bronchial asthma in the chronic persistent phase during the treatment period.Conclusion The combination of Jian'er Qiangshen electuary and Montelulast Sodium in the treatment of bronchial asthma in the chronic persistent phase with lung-spleen qi deficiency and phlegm-turbidity syndrome in children can significantly improve the control of asthma in children,enhance lung function,reduce the levels of serum inflammatory factors,regulate the levels of immunoglobulins and intestinal flora,and has high safety.