Impact of Recombinant Human Interferon Alpha-2b Vaginal Effervescent Capsules Administered at Different Timing on the Vaginal Microenvironment after Cervical Conization in Patients with Cervical Intraepithelial Neoplasia Accompanied by HPV Infection

WU Tong; WANG Min; SHI Shaohua; ZHANG Junhui

doi:10.3969/j.issn.1002-3429.2025.13.014

Abstract：Objective To analyze the impact of recombinant human interferon alpha-2b vaginal effervescent cap-sules applied at different timing on the vaginal microenvironment after cervical conization for patients with cervical intraepi-thelial neoplasia(CIN)accompanied by human papillomavirus(HPV)infection.Methods A total of 360 patients with CIN accompanied by HPV infection treated from February 2021 to February 2024 were selected and divided into group A,group B,and group C based on different treatment regimens,with 120 patients in each group.All three groups underwent cervical conization.Specifically,group A received preoperative treatment with recombinant human interferon alpha-2b vaginal effer-vescent capsules,group B was given the same drug before surgery and at 1 d after surgery,and group C was given the same drug before surgery and at 1 month postoperatively after the completion of the first menstrual cycle.The clinical efficacy and HPV clearance rate were compared among the three groups.Additionally,the recovery of vaginal microecology,vaginal local inflammation-related indicators[interleukin-4(IL-4),white blood cell(WBC)count,interferon gamma(IFN-γ),C-reactive protein(CRP)],wound healing time,and complications were statistically analyzed.Results The total effective rate,com-plete HPV clearance rate,and vaginal microecological recovery rate in group B were higher than those in group C and group A(P<0.05).The pH value of vaginal secretions in group B was lower than that in group C and group A(P<0.05).At 6 months after treatment,the levels of IL-4,CRP,and WBC count in group B were lower than those in group C and group A,while the level of INF-γ was higher than that in group C and group A(P<0.05).The wound healing time in group B was shorter than that in group C and group A(P<0.05).There was no significant difference in the incidence of complications among the three groups within six months after treatment(P>0.05).The length of the cervical canal was shorter in all three groups after treatment than that before treatment(P<0.05),but there was no significant difference between the groups(P>0.05).Conclusion The use of recombinant human interferon alpha-2b vaginal effervescent capsules before and early after cervical conization in patients with CIN accompanied by HPV infection can accelerate wound healing,reduce inflammatory response,improve vaginal microenvi-ronment,and increase the HPV clearance rate,which is beneficial to the disease prognosis.